Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience

Authors

DOI:

https://doi.org/10.21613/GORM.2019.978

Keywords:

Clomiphene, Follicle-stimulating hormone, Ovulation induction, Pregnancy, Progesterone

Abstract

Objective: This aim of this study is to assess the ovulation induction cycles based on clomiphene citrate and gonadotropin administration and specify the factors associated with successful outcomes.

Study Design: This is a prospective study of 631 patients who underwent 917 ovulation induction cycles. While clomiphene citrate was used in 680 cycles (74.2%) and recombinant follicle-stimulating hormone was administered in 237 cycles (25.8%).

Results: A total of 153 pregnancies were achieved in 917 ovulation induction cycles, indicating a clinical pregnancy rate of 16.7%. The ovulation induction cycles which ended up with clinical pregnancy had a significantly lower frequency of smoking (p=0.005), shorter infertility duration (p=0.001), higher basal luteinizing hormone (p=0.021) and lower basal progesterone (p=0.008) than unsuccessful cycles. The clomiphene citrate cycles which ended up with clinical pregnancy had a significantly lower frequency of smoking (p=0.011), shorter infertility duration (p=0.001) and lower basal progesterone (p=0.013) than the unsuccessful cycles. The recombinant follicle-stimulating hormone cycles which ended up with clinical pregnancy had a significantly higher basal luteinizing hormone (p=0.008) than the unsuccessful cycles. Basal luteinizing hormone and progesterone concentrations could significantly distinguish the patients who were able to conceive in ovulation induction cycles (p=0.021 and p=0.008, respectively).

Conclusions: Smoking, longer duration of infertility, and elevated basal progesterone are poor prognostic factors for clinical pregnancy in clomiphene citrate and recombinant follicle-stimulating hormone cycles.

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Published

2020-03-20

How to Cite

1.
Gurlek B, Batioglu AS, Kanat-Pektas M, Kale I, Onal O, Yilmaz-Karakas N. Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. Gynecol Obstet Reprod Med [Internet]. 2020Mar.20 [cited 2022May20];26(1):31-7. Available from: https://gorm.com.tr/index.php/GORM/article/view/978

Issue

Section

Reproductive Medicine: Endocrinology and Infertility