Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis?

Authors

DOI:

https://doi.org/10.21613/GORM.2019.949

Keywords:

25-hydroxy vitamin D, Dysmenorrhea, Endometrioma, Endometriosis, Vitamin D

Abstract

Objective: To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis.

Study design: A total of 53 women with endometriosis and 37 women without endometriosis were evaluated in a, case-controlled study. The demographic features, clinical, and laboratory parameters of the two groups were compared.

Results: The serum 25-hydroxy vitamin D levels were significantly decreased in both stage 1-2 and stage 3-4 groups compared to the controls (p<0.001 and p<0.001); although the difference between the stage 1-2 and stage 3-4 groups remained nonsignificant. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma (8.4±2.7 ng/mL vs 11.1±5.6 ng/mL, p=0.047). Mean serum 25-hydroxy vitamin D levels in women with and without dysmenorrhea were not significantly different from each other in the endometriosis and non-endometriosis subgroups. Serum 25-hydroxy vitamin D had no correlation with dysmenorrhea-VAS scores (r=-0.157, p=0.267).

Conclusion: The mean serum 25-hydroxy vitamin D levels were significantly decreased in both mild and moderate to severe endometriosis groups compared to the controls. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma.

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Published

2021-08-02

How to Cite

1.
Tuten N, Acikgoz S, Mammadov Z, Malik E, Tuten A, Guralp O. Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis?. Gynecol Obstet Reprod Med [Internet]. 2021Aug.2 [cited 2021Nov.28];27(2):132-7. Available from: https://gorm.com.tr/index.php/GORM/article/view/949

Issue

Section

Reproductive Medicine: Endocrinology and Infertility

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