Thrombocyte Alterations in Pregnant Women with Gestational Diabetes Mellitus

Authors

  • Senol Senturk Recep Tayyip Erdoğan University, Faculty of Medicine
  • Mehmet Kagitci Mersin State Hospital
  • Emine Seda Guvendag Guven Karadeniz Technical University, School of Medicine, Trabzon, Turkey

DOI:

https://doi.org/10.21613/GORM.2017.711

Keywords:

Diabetes mellitus, Pregnancy, Gestational diabetes, Platelet activation

Abstract

Objective: Inflammation and its complications might develop in patients diagnosed with diabetes mellitus. It is shown that number, shape and functions of thrombocytes are important for development and prediction of inflammatory process. We aimed to show the changes of number, morphology and functions of platelets in the patients with gestational diabetes mellitus.

study design: In a retrospective study, 928 cases in 24-28th weeks of gestation followed regularly in the same clinic were included. We performed 75g oral glucose tolerance test to all cases. Mean platelet volume, platelet distribution width and plateletcrit values of the cases with and without gestational diabetes mellitus according to American Diabetes Association criteria were compared to evaluate the platelet count, morphology, functions and activity.

Results: Platelet count and plateletcrit values of cases were significantly higher in the patients with gestational diabetes mellitus. No significant differences were found between the cases with and without gestational diabetes mellitus in mean platelet volume and platelet distribution width values.

Conclusion: There is tendency to inflammation in GDM and platelets are part of inflamatuary process in human metabolism. Our findings show that, platelets are affected in GDM. We believe that further studies in this subject will help understanding of pathophysiology of GDM.

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Author Biographies

Senol Senturk, Recep Tayyip Erdoğan University, Faculty of Medicine

Department of Obstetrics and Gynecology

Mehmet Kagitci, Mersin State Hospital

Department of Gynecology and Obstetrics,

Emine Seda Guvendag Guven, Karadeniz Technical University, School of Medicine, Trabzon, Turkey

Department of Obstetrics and Gynecology

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Published

2018-04-30

How to Cite

1.
Senturk S, Kagitci M, Guvendag Guven ES. Thrombocyte Alterations in Pregnant Women with Gestational Diabetes Mellitus. Gynecol Obstet Reprod Med [Internet]. 2018Apr.30 [cited 2022May26];24(1):12-6. Available from: https://gorm.com.tr/index.php/GORM/article/view/711

Issue

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

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