Preoperative Positron-Emision Tomography/Computed Tomography Findings in Endometrial Cancer: A Study of 30 Cases

Authors

  • Duygu Altın Ankara University Faculty of Medicine Department of Gynecology and Obstetrics
  • Dila Zengin Kasapoğlu Kings College Hospital, Harris Birthright Research Center, London
  • Zafer Selçuk Tuncer Hacettepe University Faculty of Medicine, Department of Gynecology and Obstetrics

DOI:

https://doi.org/10.21613/GORM.2016.657

Keywords:

Endometrial neoplasms, Positron-emission tomography, Diagnostic imaging, Sensitivity and specificity

Abstract

Objective: The aim of this study was to find out if preoperative PET/CT could be a substitute for staging surgery and whether SUVmax values correlate with prognostic factors of endometrium cancer.
Study Design: 30 patients to whom18-fluorodeoxyglucose PET/CT scan was performed preoperatively were analyzed retrospectively. Standardized uptake value (SUV) was calculated on PET images. PET findings were compared with surgical and pathological findings.
Results: SUVmax of the endometrioid type tumors were significantly higher than non-endometrioid types (p: 0.042). SUVmax significantly differ between histologic grades (p: 0.042). SUVmax did not differ between patients who had myometrial invasion less or more than 50% and who had lymphovascular invasion or not. There was not a significant difference between SUVmax and FIGO stages also. Possibility of extra-uterine lesion in PET/CT were significantly higher in late stages (p: 0.004). Sensitivity and specificity of PET/CT for detection of beyond stage 1 disease were 50% and 67% respectively and sensitivity and specificity of PET/CT for detection of lymph node metastasis were 40% and 86% respectively.
Conclusion: PET/CT has moderate sensitivity for pre-operative detection of beyond stage 1 cancers but it has a high specificity and low-moderate sensitivity for detection of lymph node metastasis but has high specificity. Because the positive likelihood ratios are relatively low, PET/CT cannot be a substitute for staging surgery.

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Published

2017-08-22

How to Cite

1.
Altın D, Kasapoğlu DZ, Tuncer ZS. Preoperative Positron-Emision Tomography/Computed Tomography Findings in Endometrial Cancer: A Study of 30 Cases. Gynecol Obstet Reprod Med [Internet]. 2017Aug.22 [cited 2022May26];23(2):94-9. Available from: https://gorm.com.tr/index.php/GORM/article/view/657

Issue

Section

Gynecology and Gynecological Oncology