Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality

Authors

  • Yasemin Alanay Clinical Genetics Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara
  • Ersin Gümüş Medical Student, Hacettepe University Faculty of Medicine, Ankara
  • Miray Sekkin Medical Student, Hacettepe University Faculty of Medicine, Ankara
  • Sebile Güler Medical Student, Hacettepe University Faculty of Medicine, Ankara
  • Nur Çakar Department of Histology and Embryology, Hacettepe University Faculty of Medicine, Ankara

Keywords:

Heterotaxy, Laterality, Situs anomalies

Abstract

Asymmetry of the left-right (L-R) axis is a feature of vertebrates that is apparent in the viscera and vasculature. An understanding of L-R patterning in human dev elopment is aided by familiarity with key events and important pathways in mammalian embryogenesis.The induction of L-R asymmetry follows the establishment of the anteroposterior (A-P or rostrocaudal) and dorsov entral (D-V) axes and requires the pre-existing midline symmetry to be broken before sidedness is induced via a series of complex, coordinated molecular signaling events. In this review, our aim is to describe the molecular background of this embryological process, and give brief knowledge concerning its clinical consequences.

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Published

2006-04-17

How to Cite

1.
Alanay Y, Gümüş E, Sekkin M, Güler S, Çakar N. Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality. Gynecol Obstet Reprod Med [Internet]. 2006Apr.17 [cited 2022Aug.8];12(1):70-8. Available from: https://gorm.com.tr/index.php/GORM/article/view/572

Issue

Section

Review