Chorionic Villus Sampling: Results of 135 High Risk Cases
Keywords:P renatal diagnosis, Chorionic villus sampling, Transabdominal, First-trimester, Outcome
OBJECTIVE: To assess the data related to the first-trimester chorionic villus sampling performed in a single tertiary center.
STUDY DESIGN: Transabdominal CVS perf ormed on 135 pregnant women, aged 18 to 38 y ears, at 11 to 14 weeks’ gestation, who sought prenatal diagnosis for v arious reasons, during the years 2000-2004. Procedure related f etal loss rate, the indications, results of cytogenetic analy sis and the clinical outcomes of patients was obtained retrospectiv ely.
RESULTS: The indications f or prenatal diagnosis were enzymatic/DNA analysis f or single gene def ects (31.1%), adv anced positive screening test result (22.2%), advanced maternal age (17.8%), and maternal anxiety (11.9%). Kary oty ping was totally successful and chromosomal abnormality was detected in 3 women (2.2%). The procedure related f etal loss rate was 0.0%.
CONCLUSION: CVS perf ormed 11-14 weeks of gestation by experienced operators is a quick, reliable, and saf e diagnostic method for prenatal diagnosis and the ov erall incidence of antenatal and neonatal complications is no greater than that expected f or a general population.
How to Cite
All the articles published in GORM are licensed with "Creative Commons Attribution 4.0 License (CC BY 4.0)". This license entitles all parties to copy, share and redistribute all the articles, data sets, figures and supplementary files published in this journal in data mining, search engines, web sites, blogs and other digital platforms under the condition of providing references.