The Affect of Pentoxifylline on Sperm Parameters in Normozoospermic, Asthenozoospermic and Oligo-Asthenozoospermic Males

Authors

  • Süheyla Çetintaş Department of Obstetrics and Gynecology Başkent University Faculty of Medicine, Ankara
  • İbrahim Esinler Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine Ankara
  • Tülay Durak Department of Obstetrics and Gynecology Başkent University Faculty of Medicine, Ankara
  • Mesut Öktem Department of Obstetrics and Gynecology Başkent University Faculty of Medicine, Ankara
  • Esra Kuşçu Department of Obstetrics and Gynecology Başkent University Faculty of Medicine, Ankara
  • Hulusi Zeyneloğlu Department of Obstetrics and Gynecology Başkent University Faculty of Medicine, Ankara

Keywords:

Pentoxifylline, Asthenozoospermia, oligoasthenozoospermia, male infertility, sperm motility, sperm morphology

Abstract

OBJECTIVE: To determine the affect of pentoxifylline (PTX) on sperm parameters in normozoospermic, asthenozoospermic, and oligo-asthenozoospermic males.
STUDY DESIGN: Each semen sample collected from normozoospermic (n=20), asthenozoospermic (n=20), and oligo-asthenozoospermic (n=20) males was divided into two equal parts. One part of the semen sample washed using Puresperm only (NidaCon, Sweden) (After-wash category) and other part was treated with pentoxifylline after washing with Puresperm (PTX-treated category). The semen parameters of the after-wash and PTX-treated categories were compared.
RESULTS: PTX-treated category was demonstrated significant increment of sperm concentration and rate of sperm with intact acrosome (SIA) when compared to after-wash group in both asthenozoospermic and oligo-asthenozoospermic males. In addition, PTX-treated group resulted higher sperm morphology in oligo-asthenozoospermic males when compared to after-wash group. However, PTX did not show any superiority on after-wash group in normozoospermic males.
CONCLUSIONS: Pentoxifylline have beneficial effect on sperm parameters especially in oligo-asthenozoospermic and asthenozoospermic patients.

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Published

2007-04-15

How to Cite

1.
Çetintaş S, Esinler İbrahim, Durak T, Öktem M, Kuşçu E, Zeyneloğlu H. The Affect of Pentoxifylline on Sperm Parameters in Normozoospermic, Asthenozoospermic and Oligo-Asthenozoospermic Males. Gynecol Obstet Reprod Med [Internet]. 2007Apr.15 [cited 2022Jan.26];13(1):38-42. Available from: https://gorm.com.tr/index.php/GORM/article/view/510

Issue

Section

Reproductive Medicine: Endocrinology and Infertility

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