The Affect of Pentoxifylline on Sperm Parameters in Normozoospermic, Asthenozoospermic and Oligo-Asthenozoospermic Males
Keywords:Pentoxifylline, Asthenozoospermia, oligoasthenozoospermia, male infertility, sperm motility, sperm morphology
OBJECTIVE: To determine the affect of pentoxifylline (PTX) on sperm parameters in normozoospermic, asthenozoospermic, and oligo-asthenozoospermic males.
STUDY DESIGN: Each semen sample collected from normozoospermic (n=20), asthenozoospermic (n=20), and oligo-asthenozoospermic (n=20) males was divided into two equal parts. One part of the semen sample washed using Puresperm only (NidaCon, Sweden) (After-wash category) and other part was treated with pentoxifylline after washing with Puresperm (PTX-treated category). The semen parameters of the after-wash and PTX-treated categories were compared.
RESULTS: PTX-treated category was demonstrated significant increment of sperm concentration and rate of sperm with intact acrosome (SIA) when compared to after-wash group in both asthenozoospermic and oligo-asthenozoospermic males. In addition, PTX-treated group resulted higher sperm morphology in oligo-asthenozoospermic males when compared to after-wash group. However, PTX did not show any superiority on after-wash group in normozoospermic males.
CONCLUSIONS: Pentoxifylline have beneficial effect on sperm parameters especially in oligo-asthenozoospermic and asthenozoospermic patients.
How to Cite
All the articles published in GORM are licensed with "Creative Commons Attribution 4.0 License (CC BY 4.0)". This license entitles all parties to copy, share and redistribute all the articles, data sets, figures and supplementary files published in this journal in data mining, search engines, web sites, blogs and other digital platforms under the condition of providing references.