Screening By Magnetic Resonance Imaging May Be Performed Even In Patients With Mild-Moderate Hyperprolactinemia

Authors

  • Gürkan Bozdağ Hacettepe University, School of Medicine, Department of Obstetrics and Gynecology, Ankara
  • Özgür Özyüncü Hacettepe University, School of Medicine, Department of Obstetrics and Gynecology, Ankara
  • Cavit Kart Hacettepe University, School of Medicine, Department of Obstetrics and Gynecology, Ankara
  • İbrahim Esinler Hacettepe University, School of Medicine, Department of Obstetrics and Gynecology, Ankara
  • Lale Karakoç Sökmensüer Hacettepe University, School of Medicine, Department of Histology and Embryology, Ankara
  • Tarık Aksu Hacettepe University, School of Medicine, Department of Obstetrics and Gynecology, Ankara
  • Serdar Günalp Hacettepe University, School of Medicine, Department of Obstetrics and Gynecology, Ankara

Keywords:

Prolactin, Magnetic resonance imaging, Microadenoma, Macroadenoma

Abstract

OBJECTIVE: To evaluate the association between the degree of hyperprolactinemia and the possibility of presenting a pituitary adenoma with magnetic resonance imaging. In addition, a threshold value for prolactin level was studied in order to predict micro/macroadenoma.
STUDY DESIGN: A total of 43 patients from a tertiary center, with persistent hyperprolactinemia were retrospectively evaluated. Only patients with a prolactin level more than 20ng/mL with two consecutive analyses were undertaken. Magnetic resonance imaging (MRI) was performed to all cases.
RESULTS: Of the 43 cases, microadenoma and macroadenoma was observed in 14 (32.6%) and 1 (%2.3) patient, respectively. The mean levels of PRL among patients with normal pituary imaging and microadenomas were similar. The unique case with macroadenoma had a PRL level of 56.2ng/mL. When the patients (n=39) were enrolled according to PRL levels, such as <100 ng/mL (n=33) or ≥100 ng/mL (n=6), the possibility of carrying a microadenoma was found to be 33.3% and 50%, respectively (p>0.5).
CONCLUSION: There is no consensus for the cut-off PRL level to predict micro/macroadenoma in patients with persistent hyperprolactinemia. According to limited data, micro/macroadenoma may be presented even in PRL levels less than 100ng/ml. Therefore, the possibility of micro/macroadenoma should not be underestimated in patients with mild-moderate hyperprolactinemia according to the available literature.

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Published

2007-04-15

How to Cite

1.
Bozdağ G, Özyüncü Özgür, Kart C, Esinler İbrahim, Karakoç Sökmensüer L, Aksu T, Günalp S. Screening By Magnetic Resonance Imaging May Be Performed Even In Patients With Mild-Moderate Hyperprolactinemia. Gynecol Obstet Reprod Med [Internet]. 2007Apr.15 [cited 2022Aug.17];13(1):29-31. Available from: https://gorm.com.tr/index.php/GORM/article/view/507

Issue

Section

Reproductive Medicine: Endocrinology and Infertility

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