Histopathological Efficacy of Docetaxel Versus Paclitaxel As First Line Chemotherapy for Epithelial Ovarian Carcinoma
Keywords:Paclitaxel, Docetaxel, Ovarian cancer
OBJECTIVE: To evaluate and compare efficacy of docetaxel and paclitaxel combining with carboplatin in the first line chemotherapy of epithelial ovarian carcinoma according to hystopathological findings of second look laparatomy.
STUDY DESIGN: Thirty two patients having stage II-IV epithelial ovarian cancer (17 cases in the paclitaxel-carboplatin group,15 cases in the docetaxel-carboplatin group) and operated in Department of Obstetrics and Gynecology, Division of Gynecologic Oncology were entered in this study. The cases were randomized for the treatment. All cases had inform-consent about the treatment options and second
look procedures. The cases who completed chemotherapy and had a second look laparatomy were included the study. Pathological responses were evaluated with second look findings proved with biopsy. Statistical analyses were performed with Chi square and Mann-Whitney U tests. Survival analyses were calculated with using Kaplan-Meier survival analyses and Log Rank test. P>0.05 was accepted for statistical significance.
RESULTS: There were no differences in demographic characteristics and rate of optimal cytoreduction between two groups. Eight cases (47,1%) in the paclitaxel-carboplatin group and 3 cases (20%) in the docetaxel-carboplatin group were hystopathological tumor positive in the second look operation without statistically significance. Also there was no significant difference between two groups in mean survival time(p 0.06).
CONCLUSION: Efficacy of docetaxel and paclitaxel are the same in terms of hystopathological findings of second look laparatomy in the treatmet of first-line epithelial ovarian cancer.
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