Cytologic and Clinical Evaluation of Human Papillomavirus in Women Underwent Routine Gynecologic Examination

Authors

  • Zehra Safi Öz Zonguldak Karaelmas University, Faculty of Medicine, Department of Medical Biology, Zonguldak
  • Şayeste Demirezen Hacettepe University, Faculty of Science, Department of Biology, Ankara
  • Gamze Mocan Kuzey Hacettepe University, Faculty of Medicine, Department of Pathology, Ankara
  • Mehmet Sinan Beksaç Hacettepe University, Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara
  • Şemsettin Ustaçelebi Hacettepe University, Faculty of Medicine, Department of Microbiology and Clinic Microbiology, Ankara

Keywords:

Human Papillomavirus, Polymerase chain reaction (PCR), Pap smear, Koilocytotic cell

Abstract

OBJECTIVE: To determine the frequency of Human Papillomavirus infection in routine gynecologic examination and to detect whether there is a relationship between the presence of Human Papilloma Virus and cytologic and gynecological findings.
STUDY DESIGN: Four hundred women applying to Gynecology outpatient clinic for routine gynecologic examination were included. Conventional Pap smears of 400 patients were stained by Papanicolaou technique and examined cytologically. HPV DNA was detected by in-house PCR . Also HPV positive samples were evaluated for HPV 16 and 18 by same method.
RESULTS: Eleven (2.75%) of 400 women were HPV DNA (+). Two of which were type 16 and 18 and one of which was type 18. Nuclear membrane irregularity, hyperchromatism, koilocytotic cell, vacuolisation and post partum period corralated with HPV infection (p <0.05).
CONCLUSION: Pap smear examination is a value of detection of cellular changes belonging Human Papillomavirus and if in this examination it is need to, these patients refer to Human Papillomavirus DNA screening it would be more cost effective.

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Published

2009-08-12

How to Cite

1.
Öz ZS, Demirezen Şayeste, Mocan Kuzey G, Beksaç MS, Ustaçelebi Şemsettin. Cytologic and Clinical Evaluation of Human Papillomavirus in Women Underwent Routine Gynecologic Examination. Gynecol Obstet Reprod Med [Internet]. 2009Aug.12 [cited 2022Jul.5];15(2):94-9. Available from: https://gorm.com.tr/index.php/GORM/article/view/410

Issue

Section

Gynecology and Gynecological Oncology

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