Increased Insulin Levels Independent of Gestational Overweight in Women with Preeclampsia

Abstract

OBJECTIVE: To evaluate whether increased insulin levels are independent of gestational overweight in women with preeclampsia.
STUDY DESIGN: The patients studied were selected at the Zeynep Kamil Woman and Children’s Hospital during their 29th and 40th week of pregnancy. The patients were evaluated in the four groups according to the diagnosis of preeclampsia (PE) and body mass index (BMI), group 1 overweight patients with mild preeclampsia (n=20), group 2 overweight patients without preeclampsia (n=20), group 3 nonoverweight patients with mild preeclampsia (n=20), and group 4 non-overweight patients without preeclamp sia (n=20). The serum fasting glucose and immunorective insulin levels were determined, and Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated.
RESULTS: The results show that there is no relation between high and normal BMI values and insulin resistance in patients with preeclampsia. Although, it was found that the HOMA-IR values of the patients with PE were higher than without PE.
CONCLUSIONS: The results indicate that there was no relation between the increased insulin resistance and the weight gain. Increased insulin resistance should be developed as a result of the pathophysiology of the preeclampsia itself.