Effect of Ovulation Induction on Ovarian Histologies in a Rat Model

Authors

  • Özlem Ulusoy Department of Obstetrics and Gynecology Scholl of Medicine Ondokuz Mayıs University, Samsun
  • Davut Güven Department of Obstetrics and Gynecology Scholl of Medicine Ondokuz Mayıs University, Samsun
  • Yurdanur Süllü Department of Pathology Scholl of Medicine Ondokuz Mayıs University, Samsun
  • Özgür Erdoğan Department of Obstetrics and Gynecology Scholl of Medicine Ondokuz Mayıs University, Samsun
  • İsmail Kılıço Department of Obstetrics and Gynecology Scholl of Medicine Ondokuz Mayıs University, Samsun
  • Cazip Üstün Department of Obstetrics and Gynecology Scholl of Medicine Ondokuz Mayıs University, Samsun
  • İdris Koçak Department of Obstetrics and Gynecology Scholl of Medicine Ondokuz Mayıs University, Samsun

Keywords:

Ovulation induction, Ki-67 expression, Dysplasia score

Abstract

OBJECTIVE: To examine the effect of human menopausal gonadotropin(HMG) and follitropinBeta (rFSH) on the ovarian histologies in a rat model.
STUDY DESING:Thirty-nine female, one-year old rats were enrolled for the trial. They were divided into three groups. In the first group, 13 rats received, six cycles of ovulation induction with human menapausal gonadotropin.In the second group, 13 rats received six cycles of ovulation induction with folitropin beta the third study group consisted of 13 rats which received six cycles of saline intramuscularly.
RESULT: The mean number of the cells that stained positive for Ki-67 was 42.3±20.6, 44.9±27.3and 42.5±24.8 in the folicles, respectively.The mean number of cells that stained positive for Ki-67 in epithelium was 0.15±0.42, 0.04±0.14,0.05±0.18, respectively. The mean dysplasiascore was 2.46±2.10,
1.69±13 and 1.62±1.89 in the ovarian epithelial cells respectively.
CONCLUSION:Development of malignant lesion were not found in any of the rat ovaries after ovulation induction. As a result of this study, we found out that human menapausal gonodotropin and folitropin beta used in treatment of infertility, when administered for six cycles in accordence with the dosage determined, do not have the potential to develop neoplasia in rats.

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Published

2009-04-11

How to Cite

1.
Ulusoy Özlem, Güven D, Süllü Y, Erdoğan Özgür, Kılıço İsmail, Üstün C, Koçak İdris. Effect of Ovulation Induction on Ovarian Histologies in a Rat Model. Gynecol Obstet Reprod Med [Internet]. 2009Apr.11 [cited 2022Jul.7];15(1):30-3. Available from: https://gorm.com.tr/index.php/GORM/article/view/378

Issue

Section

Reproductive Medicine: Endocrinology and Infertility

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