Factor 5 Leiden Gene Mutation in Endometrium Cancer

Authors

  • Rengin Karataylı Selcuk University Meram Medicine Faculty, Departments of Obstetrics & Gynecology, Konya
  • Suna Özdemir Selcuk University Meram Medicine Faculty, Departments of Obstetrics & Gynecology, Konya
  • Çetin Çelik Selcuk University Meram Medicine Faculty, Departments of Obstetrics & Gynecology, Konya
  • Osman Balcı Selcuk University Meram Medicine Faculty, Departments of Obstetrics & Gynecology, Konya
  • Süleyman Nergis Selcuk University Meram Medicine Faculty, Departments of Genetics, Konya
  • Hasan Acar Selcuk University Meram Medicine Faculty, Departments of Genetics, Konya

Keywords:

Endometrial cancer, Thrombophilia, Factor 5 leiden

Abstract

OBJECTIVE: In this study, our aim was to investigate the frequency of mutations on factor 5 Leiden gene (G1691A, A4070G, A5279G loci) in endometrial cancer patients.
STUDY DESING: 216 patients who admitted to Selcuk University Meram Faculty of Medicine Obstetrics and Gynecology Department with similar complaints (such as postmenopausal bleeding and dysfunctional uterine bleeding) were included in the study. Patients were divided into 2 groups. In the 1st group, there were 105 endometrioid type endometrial adenocarcinoma patients and in the second group, there were 111 patients whose endometrial pathology reported as benign. Two groups are compared according to frequency of mutations on factor 5 Leiden gene (especially G1691A, A4070G, A5279G loci).
RESULTS: There were not any statistically significant differences between groups according to frequency of mutations on factor 5 Leiden gene (p=0.743).
CONCLUSION: There is no correlation between mutations of factor 5 Leiden gene with endometrial cancer

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Published

2010-12-11

How to Cite

1.
Karataylı R, Özdemir S, Çelik Çetin, Balcı O, Nergis S, Acar H. Factor 5 Leiden Gene Mutation in Endometrium Cancer. Gynecol Obstet Reprod Med [Internet]. 2010Dec.11 [cited 2022Jan.18];16(3):173-7. Available from: https://gorm.com.tr/index.php/GORM/article/view/365

Issue

Section

Gynecology and Gynecological Oncology

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