Chromosome Abnormalities in Turkish Men with Primary Infertility

Authors

  • Tayfun Güngör Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, Ankara
  • Mine Kanat Pektaş Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, Ankara
  • Müfit Günel Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Andrology, Ankara
  • Leyla Mollamahmutoğlu Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, Ankara

Keywords:

Azoospermia, Chromosomal abnormality, Klinefelter syndrome, Male infertility, Spermiogram

Abstract

OBJECTIVE: The present study aims to identify the prevalence and types of chromosome anomalies among Turkish men with primary infertility.
STUDY DESIGN: A case-control study was undertaken in 474 Turkish men with primary infertility and 450 phenotypically normal fertile men selected for the control group.
RESULTS: Azoospermia is defined to be the most frequent spermiogram abnormality within infertile men, followed by oligoasthenoteratozoospermia. Chromosomal abnormalities were demonstrated to occur significantly more in azoospermic subjects (28.3%) compared to other infertile subjects (11.5%) and fertile men (0.8%). Klinefelter syndrome was detected to be the most frequent chromosomal abnormality with an overall rate of 10.5%. Azoospermia Factor (AZF) microdeletions occur statistically similar among azoospermic men (4.2%) and other infertile men (2.3%), with a total frequency of 3.2%.
CONCLUSION: The high rate of chromosomal anomalies among infertile Turkish men strongly suggests the need for routine cytogenetic analysis prior to the application of assisted reproduction techniques.

Downloads

Download data is not yet available.

Downloads

Published

2010-04-10

How to Cite

1.
Güngör T, Kanat Pektaş M, Günel M, Mollamahmutoğlu L. Chromosome Abnormalities in Turkish Men with Primary Infertility. Gynecol Obstet Reprod Med [Internet]. 2010Apr.10 [cited 2024Dec.22];16(1):32-6. Available from: https://gorm.com.tr/index.php/GORM/article/view/332

Issue

Vol. 16 No. 1 (2010)

Section

Reproductive Medicine: Endocrinology and Infertility

License

CC BY

All the articles published in GORM are licensed with "Creative Commons Attribution 4.0 License (CC BY 4.0)". This license entitles all parties to copy, share and redistribute all the articles, data sets, figures and supplementary files published in this journal in data mining, search engines, web sites, blogs and other digital platforms under the condition of providing references.