Cytogenetic Investigation in Couples with Recurrent Abortion and Poor Obstetric History

Authors

  • Ebru Önalan Etem Fırat University Faculty of Medicine Department of Medical Biology and Genetic, Elazığ
  • Hüseyin Yüce Fırat University Faculty of Medicine Department of Medical Biology and Genetic, Elazığ
  • Deniz Erol Fırat University Faculty of Medicine Department of Medical Biology and Genetic, Elazığ
  • Şükriye Derya Deveci Fırat University Faculty of Medicine Department of Medical Biology and Genetic, Elazığ
  • Hüsnü Çelik Fırat University Faculty of Medicine Department of Obstetrics and Gynecology, Elazığ
  • Halit Elyas Fırat University Faculty of Medicine Department of Medical Biology and Genetic, Elazığ

Keywords:

Spontaneous abortion, Compleks chromosomal rearragement, Cytogenetic

Abstract

OBJECTIVES: The cause of recurrent early pregnancy wastage is often unknown. Cytogenetic studies have an important role in the evaluation of couples with repeated miscarriages and poor obstetric history.
STUDY DESIGN: To estimate the prevalence of chromosomal abnormalities and polymorphic variants, we performed G-banded chromosome analysis on 470 couples with 2 or more spontaneous abortions or bad obstetric history, the east of Turkey from 1998 to 2008.
RESULTS: Major chromosomal aberrations and polymorphic variants were found in 2.12% and 2.34%, respectively. Complex chromosomal rearragements it was detected in one female patient.
CONCLUSION: Our study suggest that chromosomal abnormality incidence in patients with fetal deaths/abnormality is much higher than in the patients with first trimester or second trimester recurrent abortion. Prenatal diagnosis should be offered to couples wiht balanced chromosomal carrier and in vitro fertilization to couples with complex chromosomal rearragements in the case of future pregnancies.

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Published

2010-04-10

How to Cite

1.
Önalan Etem E, Yüce H, Erol D, Derya Deveci Şükriye, Çelik H, Elyas H. Cytogenetic Investigation in Couples with Recurrent Abortion and Poor Obstetric History. Gynecol Obstet Reprod Med [Internet]. 2010Apr.10 [cited 2024Dec.26];16(1):4-8. Available from: https://gorm.com.tr/index.php/GORM/article/view/326

Issue

Vol. 16 No. 1 (2010)

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

License

CC BY

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