Galectin-3 Expression in Human Endometrium and Decidua During The Menstrual Cycle and in Gestation

Authors

  • Nevra Dursun Department of Pathology, Istanbul Education and Research Hospital, Istanbul
  • Melin Özgün Geçer Department of Pathology, Dr. Lütfi Kırdar Education and Research Hospital, Istanbul
  • Pelin Yıldız Department of Pathology, Istanbul Education and Research Hospital, Istanbul
  • Cem Leblebıcı Department of Pathology, Istanbul Education and Research Hospital, Istanbul
  • Erol Rüştü Bozkurt Department of Pathology, Istanbul Education and Research Hospital, Istanbul
  • Nimet Karadayı Department of Pathology, Dr. Lütfi Kırdar Education and Research Hospital, Istanbul
  • Fadime Bahadır Department of Pathology, Istanbul Education and Research Hospital, Istanbul

Keywords:

Endometrium, Galectin-3, Secretory, Proliferative, Decidua.

Abstract

OBJECTIVE: G3 is one of the members of the lectin family that may be involved in the establishment of endometrial receptivity by regulating the proliferation and adhesion of endometrial cells.
STUDY DESIGN: Immunohistochemical expression of G3 was tested in late secretory phase of the endometrium (SPE)(n=30), proliferative phase of the endometrium (PPE)(n=34), and decidua (n=41) and induced abortions in the first trimester.
RESULTS: Expression of G3 during the PPE was low; 12 cases were score 1 and 19 cases were score 2 (p<0.001). However, among the late SPE, there were 11 cases at score 2, and 15 cases at score 3. In the decidua expression of G3, 37 cases were score 3 (p<0.001).
CONCLUSION: There is a significant progression of G3 expression in SPE and gestation. Although during the PPE expression is considerably lower. This shows that G3 plays an important role in implantation.

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Published

2011-04-09

How to Cite

1.
Dursun N, Özgün Geçer M, Yıldız P, Leblebıcı C, Bozkurt ER, Karadayı N, Bahadır F. Galectin-3 Expression in Human Endometrium and Decidua During The Menstrual Cycle and in Gestation. Gynecol Obstet Reprod Med [Internet]. 2011Apr.9 [cited 2024Nov.25];17(1):24-7. Available from: https://gorm.com.tr/index.php/GORM/article/view/282

Issue

Vol. 17 No. 1 (2011)

Section

Reproductive Medicine: Endocrinology and Infertility

License

CC BY

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