Candida and Toll-Like Receptors

Authors

  • Şayeste Demirezen Hacettepe University Faculty of Natural & Applied Science Department of Biology, Ankara
  • Ayşegül Yücel Hacettepe University Faculty of Natural & Applied Science Department of Biology, Ankara
  • Mehmet Sinan Beksaç Hacettepe University Faculty of Medicine Department of Obstetrics and Gynecology, Ankara

Keywords:

Candida, Toll-like receptor, Infection

Abstract

Candida is a dimorphic fungus living as a commensal organism in human vagina. However it can cause infection under some conditions. Some factors, such as stratification of vaginal epithelial cells, natural flora and acidic pH, prevent infection by this organism. Recent studies identified that Toll-like receptor (TLR) proteins also play a role in protecting against infection. These receptors recognize Candida cell wall components such as β-glucans, mannoproteins and chitin. When TLR’s interact with these biomolecules, TLR signaling pathway become active and various cytokines are produced. Morphogenesis from yeast form to pathogenic hyphal form is inhibited by these cytokines. In our review, we aim to clarify Candida, vulvovaginal candidiasis, TLRs and relationship between TLRs and Candida.

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Published

2012-12-06

How to Cite

1.
Demirezen Şayeste, Yücel A, Beksaç MS. Candida and Toll-Like Receptors. Gynecol Obstet Reprod Med [Internet]. 2012Dec.6 [cited 2022Jul.5];18(3):176-8. Available from: https://gorm.com.tr/index.php/GORM/article/view/276

Issue

Section

Review

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