Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies

Authors

  • Zerrin Yılmaz Baskent University Faculty of Medicine Department of Medical Genetics, Ankara
  • Özge Özer Baskent University Faculty of Medicine Department of Medical Genetics, Ankara
  • Derya Eroğlu Baskent University Faculty of Medicine Department of Obstetrics and Gyneocology, Ankara
  • Filiz Yanık Baskent University Faculty of Medicine Department of Obstetrics and Gyneocology, Ankara
  • Feride İffet Şahin Baskent University Faculty of Medicine Department of Medical Genetics, Ankara

Keywords:

Aneuploidy, Fetal ultrasonography, Prenatal diagnosis

Abstract

OBJECTIVE: The present study aims to evaluate the importance of USG findings, in estimating cytogenetic abnormality risks in pregnancies otherwise carrying low risk for aneuploidy.
STUDY DESIGN: We reviewed a number of most commonly observed soft markers and structural abnormalities in pregnant women with low risk who underwent invasive prenatal diagnostic tests for USG abnormality in the period from January 2002 to December 2008, retrospectively. In 179 of all cases (9.95%), cytogenetic analysis was recommended because of USG abnormality.
RESULTS: 76 patients had structural abnormalities, 95 had soft markers and 8 had intra-uterine growth restriction. We detected 12 aneuploidies in fetuses with structural abnormalities and 1 aneuploidy in fetuses with soft markers.
CONCLUSION: We concluded that, although the presence or absence of soft markers can substantially modify the risk of fetal aneuploidy, one or more structural abnormalities inevitably have high risk for aneuplodies as independent factor for low-risk pregnancies.

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Published

2012-04-06

How to Cite

1.
Yılmaz Z, Özer Özge, Eroğlu D, Yanık F, Şahin F İffet. Importance of Routine Ultrasonography in Detecting Fetal Karyotype Abnormalities in Low Risk Pregnancies. Gynecol Obstet Reprod Med [Internet]. 2012Apr.6 [cited 2022Jan.26];18(1):1-6. Available from: https://gorm.com.tr/index.php/GORM/article/view/227

Issue

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

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