Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels

Authors

  • Tuba Günebak Şahin Hacettepe University Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara
  • Berkan Sayal Hacettepe University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara
  • Erdal Coşgun Hacettepe University Faculty of Medicine, Department of Bioistatistics, Ankara
  • Tanju Besler Hacettepe University Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara
  • Sinan Beksaç Hacettepe University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara

Keywords:

Methylenetetrahydrofolate reductase, Homocysteine, Folic acid, Vitamin B12

Abstract

OBJECTIVE: The purpose of this study is to investigate the influence of MTHFR gene polymorphisms which may effect the interaction in between homocysteine, folic acid and vitamin B12 metabolisms.
STUDY DESIGN: The subject of this study is consisted of 165 patients who were obtained from “Hacettepe University Maternal Fetal Medicine Data Base”. These were married women of childbearing age with MTHFR gene polymorphisms who experienced bad obstetrical history. Plasma total homocysteine, serum folic acid and vitamin B12 levels of the subjects were analysed and the interrelation between these nutritional factors was examined.
RESULTS: Both folic acid and vitamin B12 are significantly important and effective factors in homocysteine metabolism in MTHFR mutant subjects.
CONCLUSION: Folic acid is a much more important mass measure for controlling elevation of plasma homocysteine concentration.

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Published

2013-04-30

How to Cite

1.
Günebak Şahin T, Sayal B, Coşgun E, Besler T, Beksaç S. Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels. Gynecol Obstet Reprod Med [Internet]. 2013Apr.30 [cited 2022Aug.8];19(1):1-6. Available from: https://gorm.com.tr/index.php/GORM/article/view/171

Issue

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

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