Utilizing the Prognostic Nutritional Index to Predict Chemotherapy Toxicities in Ovarian Cancer Patients: Long-Term Tertiary Center Experiences

Ayse  Gulen Erturun; secil Tashan Donercark; Mustafa Alperen Aksan; Nurettin Boran; Sinem Ayse Duru Coteli; Yaprak Ustun

doi:10.21613/GORM.2025.1645

Utilizing the Prognostic Nutritional Index to Predict Chemotherapy Toxicities in Ovarian Cancer Patients: Long-Term Tertiary Center Experiences

Authors

Ayse Gulen Erturun Etlik Zübeyde Hanım EAH https://orcid.org/0000-0003-0756-2463
Seçil Taşhan University of Health Sciences Bursa Higher Education and Research Hospital, Bursa, Turkey https://orcid.org/0000-0002-0248-7225
Mustafa Alperen Aksan Rize Private Şar Hospital, Rize, Turkey https://orcid.org/0000-0001-7623-3589
Nurettin Boran Department of Gynecology Oncology, Obstetrics and Gynecology University of Health Science, Ankara Etlik Zubeyde Hanım Women`s Health and Research Center Turkey, Ankara, Turkey https://orcid.org/0000-0002-0367-5551
Sinem Ayse Duru Coteli Department of Gynecology Oncology, Obstetrics and Gynecology University of Health Science, Ankara Etlik Zubeyde Hanım Women`s Health and Research Center Turkey, Ankara, Turkey https://orcid.org/0000-0002-6558-7549
Yaprak Ustun Department of Obstetrics and Gynecology, Obstetrics and Gynecology University of Health Sciences Turkey, Ankara Etlik Zubeyde Hanım Women`s Health and Research Center Turkey, Ankara, Turkey https://orcid.org/0000-0002-1011-3848

DOI:

https://doi.org/10.21613/GORM.2025.1645

Keywords:

Chemotherapy, Hematologic, Ovarian Cancer, Personalized Medicine, Prognostic Nutritional Index, Toxicity

Abstract

Objective: Our aim was to clearly evaluate the Prognostic Nutritional Index's ability to predict chemotherapy-induced toxicity in ovarian cancer patients undergoing platinum-based chemotherapy.
Study Design: This retrospective cohort study of 158 patients with epithelial ovarian cancer treated with carboplatin-paclitaxel after surgery at a university hospital from 2010 to 2020 decisively investigates the Prognostic Nutritional Index (PNI) as a predictor of chemotherapy-related toxicities. PNI was calculated using pre-treatment serum albumin levels and lymphocyte counts.
Results: The findings clearly demonstrate that patients with a PNI ≤34.10 experienced higher overall and severe hematologic toxicities compared to those with a higher PNI. Dose reductions and treatment delays were markedly more frequent in the low PNI group.
Conclusion: This study establishes that PNI is a valuable tool for assessing patient risk, though further validation will enhance its clinical utility.

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Published

2026-04-09

How to Cite

Gulen Erturun A, Tashan Donercark secil, Aksan MA, Boran N, Duru Coteli SA, Ustun Y. Utilizing the Prognostic Nutritional Index to Predict Chemotherapy Toxicities in Ovarian Cancer Patients: Long-Term Tertiary Center Experiences. Gynecol Obstet Reprod Med [Internet]. 2026Apr.9 [cited 2026May3];:1-7. Available from: https://gorm.com.tr/index.php/GORM/article/view/1645

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Issue

Articles in Press

Section

Gynecology and Gynecological Oncology

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