The Role of Triglyceride/Glucose Index in patients with Polycystic Ovary Syndrome

Ufuk Atlihan; Selcuk Erkilinc; Burak Ersak; Ferruh Acet; Ali Cenk Ozay; Onur Yavuz; Huseyin Aytug Avsar; Can Ata; Tevfik Berk Bildaci

doi:10.21613/GORM.2025.1586

The Role of Triglyceride/Glucose Index in patients with Polycystic Ovary Syndrome

Authors

Ufuk Atlihan Özel Karataş Hastanesi https://orcid.org/0000-0002-2109-1373
Selcuk Erkilinc Izmir Democracy University Faculty of Medicine https://orcid.org/0000-0002-6512-9070
Burak Ersak Ankara Bilkent City Hospital, University of Health Sciences https://orcid.org/0000-0003-3301-062X
Ferruh Acet Ege University Faculty of Medicine https://orcid.org/0000-0003-0628-0368
Ali Cenk Ozay IVF Center Cyprus https://orcid.org/0000-0002-6082-7101
Onur Yavuz Dokuz Eylul University Faculty of Medicine https://orcid.org/0000-0003-3716-2145
Huseyin Aytug Avsar Tınaztepe Galen University https://orcid.org/0000-0003-0636-3104
Can Ata Buca Seyfi Demirsoy Training and Research Hospital https://orcid.org/0000-0002-0841-0480
Tevfik Berk Bildaci Izmir Democracy University Faculty of Medicine https://orcid.org/0000-0002-6432-6777

DOI:

https://doi.org/10.21613/GORM.2025.1586

Keywords:

Insulin resistance, Polycystic ovary syndrome , Triglyceride/glucose index

Abstract

OBJECTIVE: Our study aimed to examine the function of triglyceride/glucose (TyG) index, TyG-BMI, HOMA-IR, and conventional lipid ratios in determining IR in women with PCOS and to evaluate whether the TyG index is a clinical marker for IR.

STUDY DESIGN: A total of 171 individuals with PCOS and 93 control patients who were admitted to our gynecology clinic between January 2018 and January 2024 were evaluated retrospectively. BMI, FBG, QUICKI, HOMA-β, HOMA-IR, FSH, LH, TyG-BMI, TyG, LDL-C, HDL-C, TG, TC, and fasting insulin levels of all patients were retrieved from the hospital database and evaluated retrospectively.

RESULTS: The TyG index was significantly higher (8.35±0.44) in the PCOS group compared to the control group (8.23±0.36) (p=0.04). The PCOS group had a significantly higher TyG-BMI index (217.93±46.2) than the control group (199.16±42.4) (p=0.026). The PCOS group had a substantially higher TC/HDL-C ratio (4.52±1.36) than the control group (3.94±1.62) (p=0.016). The PCOS group had a significantly higher TG/HDL-C ratio (2.75±1.18) than the control group (2.15±1.12) (p=0.008).

CONCLUSION: According to our research, the TyG index and TyG-BMI demonstrated a strong predictive power in identifying impaired insulin sensitivity in female PCOS patients. The TyG index can serve as a potential surrogate marker for calculating IR in female PCOS patients, as TG and glucose tests are both commonly performed and cost-effective. Further large-scale prospective and epidemiological studies are needed to validate these findings.

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Published

2025-08-29

How to Cite

Atlihan U, Erkilinc S, Ersak B, Acet F, Ozay AC, Yavuz O, Avsar HA, Ata C, Bildaci TB. The Role of Triglyceride/Glucose Index in patients with Polycystic Ovary Syndrome. Gynecol Obstet Reprod Med [Internet]. 2025Aug.29 [cited 2026Apr.26];31(2):130-6. Available from: https://gorm.com.tr/index.php/GORM/article/view/1586

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Issue

Vol. 31 No. 2 (2025):

Section

Reproductive Medicine: Endocrinology and Infertility

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