Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density

Ufuk Atlihan; Onur Yavuz; Huseyin Aytug Avsar; Can Ata; Tevfik Berk  Bildaci; Selcuk Erkilinc

doi:10.21613/GORM.2023.1520

Authors

Ufuk Atlihan Private Karatas Hospital, Department of Gynecology and Obstetrics https://orcid.org/0000-0002-2109-1373
Onur Yavuz Dokuz Eylul University, Institute of Health Sciences, Department of Gynecology and Obstetrics https://orcid.org/0000-0003-3716-2145
Huseyin Aytug Avsar Buca Seyfi Demirsoy Training and Research Hospital, Department of Gynecology and Obstetrics https://orcid.org/0000-0003-0636-3104
Can Ata Buca Seyfi Demirsoy Training and Research Hospital, Department of Gynecology and Obstetrics https://orcid.org/0000-0002-0841-0480
Tevfik Berk Bildaci İzmir Democracy University, Institute of Health Sciences, Department of Gynecology and Obstetrics https://orcid.org/0000-0002-6432-6777
Selcuk Erkilinc İzmir Democracy University, Institute of Health Sciences, Department of Gynecology and Obstetrics https://orcid.org/0000-0002-6512-9070

DOI:

https://doi.org/10.21613/GORM.2023.1520

Keywords:

: Early menopause, Hormone Replacement Therapy, Premature ovarian failure

Abstract

OBJECTIVE: Early menopause causes several health concerns that are related directly to the deficiency of ovarian hormones, especially estrogen insufficiency. The purpose of the research was to investigate the impact of low-dose hormone therapy on metabolic parameters and bone densitometry in patients with early menopause.

STUDY DESIGN: A total of 98 patients aged 38-42 years with an early-menopause and followed up were evaluated retrospectively in this cohort study. After the diagnosis of early menopause, combined oral contraceptive (COC) treatment including 3 mg Drospirenone + 0.02 mg Ethinylestradiol was recommended to the patients. After 1 year of COC treatment, metabolic, ultrasonographic, and bone densitometry measurements of patients who did and did not use COC regularly were compared.

RESULTS: At the 12th-month follow-up, endometrial thickness was significantly higher in the COC group (3.8±0.4 mm) compared with the non-COC group (3.5±0.4 mm) (p<0.01). At the 12th month follow-up, the estradiol value was significantly higher (16.1±1.5 pg/mL) in the COC group compared with the non-COC group (14.8±2.5 pg/mL) (p<0.01). At the 12th month follow-up, the total cholesterol value was found significantly lower in the COC group (197±24.2 mg/dL) compared with the non-COC group (211±28 mg/dL) (p<0.01). At the 12th month follow-up, the Z-score was found significantly higher in the COC group (0.02±0.3) compared with the non-COC group (0.2±0.3) (p<0.01).

CONCLUSION: Hormone replacement therapy is very important for women who enter early menopause, and adequate estrogen therapy must be taken to maintain bone density and reduce menopausal symptoms.