Hemoglobin A1c Level is Associated with Lymphovascular Space Invasion in Diabetic Endometrial Cancer Patients

Ayse Rabia Senkaya; Sercan  Kantarci; Suna  Yildirim Karaca; Muzaffer Sanci

doi:10.21613/GORM.2023.1386

Hemoglobin A1c Level is Associated with Lymphovascular Space Invasion in Diabetic Endometrial Cancer Patients

Authors

Ayse Rabia Senkaya İzmir Bakırçay University Faculty of Medicine https://orcid.org/0000-0003-1538-6965
Sercan Kantarci University of Health Sciences Tepecik Training and Research Hospital https://orcid.org/0000-0001-5608-060X
Suna Yildirim Karaca University of Health Sciences Tepecik Training and Research Hospital https://orcid.org/0000-0001-6633-0342
Muzaffer Sanci University of Health Sciences Tepecik Training and Research Hospital https://orcid.org/0000-0002-8494-4302

DOI:

https://doi.org/10.21613/GORM.2023.1386

Keywords:

Diabetes Mellitus, Endometrial Neoplasms, Glycated Hemoglobin A

Abstract

Objective: Our aim in this study is to examine the relationship of hemoglobin A1c (HbA1c) and fasting glucose with the stage, grade and histological type of cancer and its value in predicting the prognosis of endometrial cancer in diabetic endometrial cancer patients.

Study Design: The data of 138 endometrial cancer patients with diabetes who met the study criteria were analyzed. Hemoglobin A1c levels and fasting glucose were compared with cancer stage, grade, histological type, lymphovascular invasion, chemotherapy and radiotherapy data.

Results: A statistically significant difference was found between the groups in terms of HbA1c values only according to the lymphovascular invasion (p=0.02). While there was no significant correlation between endometrial thickness and HbA1c, a low positive correlation was found between the fasting glucose value (r=0.191, p=0.025)

Conclusions: The higher rate of lymphovascular invasion in patients with high HbA1c value alone is insufficient in determining the prognosis when other parameters are considered.

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Published

2024-04-28

How to Cite

Senkaya AR, Kantarci S, Yildirim Karaca S, Sanci M. Hemoglobin A1c Level is Associated with Lymphovascular Space Invasion in Diabetic Endometrial Cancer Patients. Gynecol Obstet Reprod Med [Internet]. 2024Apr.28 [cited 2024Dec.22];30(1):50-4. Available from: https://gorm.com.tr/index.php/GORM/article/view/1386

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Issue

Vol. 30 No. 1 (2024):

Section

Gynecology and Gynecological Oncology

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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