The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems

Authors

DOI:

https://doi.org/10.21613/GORM.2022.1382

Keywords:

Chorioamnionitis, Early neonatal death, Early neonatal sepsis , High-Risk Pregnancy , Perinatal morbidity , Preterm premature membrane rupture

Abstract

OBJECTIVE: Obstetric problems have detrimental effects on both pregnancy and newborn. We aimed to examine the relationship between pregnancy complications and newborn morbidities.

STUDY DESIGN: The newborns admitted to the neonatal intensive care unit between September 2019 and August 2022 were included in this retrospective cross-sectional study. Antenatal morbidities and neonatal complications including low APGAR-score (<5), bronchopulmonary dysplasia, early neonatal sepsis, and early neonatal death were evaluated. Pearson-χ2 cross-tabs were used to compare two variables. A p-value <0.05 was determined statistically significant.

RESULTS: Among the 686 infants analyzed, 94 (13.7%) had early neonatal death, 264 (38.5%) had bronchopulmonary dysplasia, 259 (37.8%) had early neonatal sepsis, and 424 (61.9%) had feeding intolerance. Early neonatal sepsis was observed significantly higher in newborns whose mothers had urinary tract infection in the last two weeks (p<0.001), preterm premature rupture of membranes (p=0.006), or clinical chorioamnionitis (p<0.001). Early neonatal death was found significantly higher in pregnancies with preeclampsia (p<0.001), preterm premature rupture of membranes (p<0.001), clinical chorioamnionitis (p<0.001), or small-for-gestational-age (p<0.001). Preeclampsia and magnesium neuroprophylaxis were found significantly higher in neonates with feeding intolerance (p<0.001). Backward: LR logistic regression analysis based on early neonatal sepsis risk revealed that birth week, preterm premature rupture of membranes, clinical chorioamnionitis, small-for-gestational-age, and urinary tract infection were significant parameters affecting the risk of early neonatal sepsis (p<0.05).

CONCLUSION: Preventing premature births and cautious management of pregnancy complications may be helpful in reducing adverse neonatal outcomes. Early detection of high-risk pregnancies and transfer to a tertiary center may be helpful to improve neonatal outcomes.

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Published

2023-03-17

How to Cite

1.
Sinaci S, Kadioglu Simsek G, Sakcak B, Ozgurluk I, Canpolat FE, Sahin D. The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems. Gynecol Obstet Reprod Med [Internet]. 2023Mar.17 [cited 2024Dec.26];29(1):1-9. Available from: https://gorm.com.tr/index.php/GORM/article/view/1382

Issue

Vol. 29 No. 1 (2023):

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

License

Copyright (c) 2023 Selcan Sinaci, Gulsum Kadioglu Simsek, Bedri Sakcak, Izzet Ozgurluk, Fuat Emre Canpolat, Dilek Sahin

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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