Leuprolide Acetate Treatment for Ovarian Cysts in Breast Cancer Patients Under Tamoxifen Therapy

Şafak Yılmaz Baran; Gulsen Dogan Durdag; Songul Alemdaroglu; Sirin Aydin; Husnu Celik

doi:10.21613/GORM.2022.1320

Leuprolide Acetate Treatment for Ovarian Cysts in Breast Cancer Patients Under Tamoxifen Therapy

Authors

Şafak Yılmaz Baran 1Department of Obstetrics and Gynecology, Acibadem Dr Sinasi Can Kadikoy Healthcare Group, Istanbul, Turkiye https://orcid.org/0000-0001-5874-7324
Gulsen Dogan Durdag baskent university https://orcid.org/0000-0002-5064-5267
Songul Alemdaroglu baskent university https://orcid.org/0000-0003-4335-6659
Sirin Aydin baskent university https://orcid.org/0000-0001-6176-925X
Husnu Celik baskent university https://orcid.org/0000-0003-1185-9227

DOI:

https://doi.org/10.21613/GORM.2022.1320

Keywords:

Breast neoplasms, Gonadotropin-releasing hormone agonist trigger, Ovary , Ovarian cyst , tamoxifen

Abstract

OBJECTIVE: The aim of this study is to evaluate the outcomes of gonadotropin-releasing hormone agonist treatment for ovarian cysts, which are developed during tamoxifen use due to breast cancer.

STUDY DESIGN: This was a retrospective cohort study including the patients who were under tamoxifen treatment due to stage I-III breast cancer and who were administered leuprolide acetate for ovarian cysts with low malignancy risk between 2012-2020.

RESULTS: Leuprolide acetate was administered to a total of 16 patients with ovarian cysts. The median age was 39.5 (33-52), the median size of the ovarian cyst was 42.5 (39-79) mm, and the median duration of tamoxifen use was 22 (7-36) months. Leuprolide acetate was administered at doses of 3.75 mg for 1 month at 10 (62.5%) patients, 7.5 mg in two months at 3 (18.75%) patients, and 11.25 mg in three months at 3 (18.75%) patients. Ovarian cysts were regressed after treatment at 13 patients, while 3 patients underwent surgery.

CONCLUSION: Leuprolide acetate can be used as an option in the treatment of ovarian cysts that develop in breast cancer patients under tamoxifen therapy.
Keywords: Breast neoplasms, Gonadotropin-releasing hormone, Ovary, Ovarian cyst, Tamoxifen

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Published

2022-12-15

How to Cite

Yılmaz Baran Şafak, Dogan Durdag G, Alemdaroglu S, Aydin S, Celik H. Leuprolide Acetate Treatment for Ovarian Cysts in Breast Cancer Patients Under Tamoxifen Therapy. Gynecol Obstet Reprod Med [Internet]. 2022Dec.15 [cited 2024Apr.23];28(3):265-9. Available from: https://gorm.com.tr/index.php/GORM/article/view/1320

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Issue

Vol. 28 No. 3 (2022):

Section

Gynecology and Gynecological Oncology

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