Prenatal Diagnosis of Isolated Lissencephaly by Ultrasonography and Magnetic Resonance Imaging: A Case Report

Authors

  • Mehmet Serdar Kütük Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Mehmet Dolanbay Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Mahmut Tuncay Özgün Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Hülya Akgün Erciyes University Faculty of Medicine Department of Pathology, Kayseri
  • Ali Yıkılmaz Erciyes University Faculty of Medicine Department of Radiology, Kayseri

Keywords:

Lissencephaly, Ultrasonography, Prenatal, Agyria, Fetal

Abstract

We present the abnormal sonographic findings in the brain of a 26-week fetus, which increased the suspicion of isolated lissencephaly. The woman had a history of prednisolone use in early pregnancy, and conceived with copper containing intra uterine device. Fetal magnetic resonance imaging and ultrasonography revealed hypoplastic cerebral parenchyma, and cortical agyria suggesting lissencephaly.
Cordocentesis showed a normal 46, XY karyotype, and no deletion of chromosome 17 was detected. Post-mortem examination of the fetus confirmed prenatal US and MRI findings. Early detection of fetal microcephaly can be a sign of lissencephaly and need to be evaluated carefully with fetal MRI, and US.

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Published

2014-04-30

How to Cite

1.
Kütük MS, Dolanbay M, Özgün MT, Akgün H, Yıkılmaz A. Prenatal Diagnosis of Isolated Lissencephaly by Ultrasonography and Magnetic Resonance Imaging: A Case Report. Gynecol Obstet Reprod Med [Internet]. 2014Apr.30 [cited 2022Jul.7];20(1):53-5. Available from: https://gorm.com.tr/index.php/GORM/article/view/131

Issue

Section

Case Reports

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