Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection

Authors

  • Burak Tanır Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Mehmet Serdar Kütük Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Mehmet Dolanbay Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Mahmut Tuncay Özgün Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Semih Uludağ Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Ercan Aygen Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri
  • Yılmaz Şahin Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri

Keywords:

Infertility, Endometriosis, ICSI, Letrozole, Gonadotropin

Abstract

OBJECTIVE: To compare the result of intracytoplasmic sperm injection cycles using gonadotrophins with those of using gonadotrophins combined with letrozole in infertile woman with biopsy-proven endometriosis.
STUDY DESIGN: This prospective randomized study was performed at the department of Obstetrics and Gynecology Reproductive Center, in Erciyes University. Thirty- three women undergoing intracytoplasmic sperm injection (ICSI) with gonadotropin or combination of gonadotropin with letrozole were accepted.
The patients were grouped as: gonadotropin group (Group 1), and gonadotropin plus letrozole (Group 2). Total and clinical pregnancy ratios, length of cycles, and doses of gonadotropin used were compared.
RESULTS: Total doses of gonadotrophins used in group 1, and group 2 were 2700 (1800- 3600) IU and 2100 (1575- 3475) IU, respectively. Total dose of gonadotropin used in group 2 was found to be lower than that of group one and this difference was statistically significant (p= 0.002). Stimulation times in group 1 and 2 were 10 (9- 12) day, and (7- 12) day, respectively, and the difference was statistically significant (p=0.048). Number of the retrieved oocytes were higher in group 2 than Group 1(p=0.027). There was no statistically significant difference between groups with regard to numbers of embryos, total and clinical pregnancy ratio.
CONCLUSIONS: Letrozole has no effect on the results of ICSI success in infertile women with biopsy proven- endometriosis. However, it reduces the gonadotropin dose used, stimulation time and, cost of the therapy.

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Published

2014-04-30

How to Cite

1.
Tanır B, Kütük MS, Dolanbay M, Özgün MT, Uludağ S, Aygen E, Şahin Y. Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection. Gynecol Obstet Reprod Med [Internet]. 2014Apr.30 [cited 2022Aug.10];20(1):38-43. Available from: https://gorm.com.tr/index.php/GORM/article/view/128

Issue

Section

Reproductive Medicine: Endocrinology and Infertility

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