Antenatal Ultrasound Findings in Fetus with Down Syndrome

Authors

  • Mehmet Serdar KÜTÜK Erciyes University Faculty of Medicine, Kayseri
  • Mahmut Tuncay ÖZGÜN Erciyes University Faculty of Medicine, Kayseri
  • Mehmet Dolanbay Erciyes University Faculty of Medicine, Kayseri
  • Gülsüm Uysal Erciyes University Faculty of Medicine
  • Aslı Uzak Erciyes University Faculty of Medicine
  • Elif Kulengir Erciyes University Faculty of Medicine
  • Semih Uludağ Erciyes University Faculty of Medicine
  • Mustafa Başbuğ Erciyes University Faculty of Medicine

Keywords:

Down syndrome, Ultrasonography, Prenatal diagnosis

Abstract

OBJECTIVE: The aim of the present study is to assess the importance and role of the ultrasound imaging in the diagnosis of Down syndrome based on our own experience.
STUDY DESIGN: The study was conducted in Erciyes University, Department of Obstetrics and Gynecology, Prenatal Diagnosis Unit between 2010-2012. The data of 67 fetus prenatally diagnosed as Down syndrome were analyzed retrospectively with special emphasizes on ultrasound findings.
RESULTS: A total of 67 women were included in the study. The main maternal age 33.5 (min-max: 18-46). The most common indication for invasive testing was advanced maternal age (23.8%). The invasive testing consisted of chorionic villus sampling (10.4%), amniocentesis (83.5%), and cordocentesis (5.9%). In 54 patients, the ultrasonographic evaluation revealed major malformation and/or Down syndrome marker (80.5%), and 38 cases had more than one marker/malformation (56.7%). The most common Down syndrome marker was mild pyelectasia (25.3%), and the most common major congenital anomaly was atrioventricular canal defect that was seen in six fetuses (8.9%).
CONCLUSION: Despite improvement in ultrasound technology and experiences, no anomaly and/or aneuploidy marker can be detected with ultrasound in a considerable proportion of fetus with Down syndrome. Therefore, invasive prenatal testing should be standard of care in the presence of abnormal serum screening for Down syndrome and/or in pregnant women of advanced maternal age.

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Published

2014-04-30

How to Cite

1.
KÜTÜK MS, ÖZGÜN MT, Dolanbay M, Uysal G, Uzak A, Kulengir E, Uludağ S, Başbuğ M. Antenatal Ultrasound Findings in Fetus with Down Syndrome. Gynecol Obstet Reprod Med [Internet]. 2014Apr.30 [cited 2024Mar.28];20(1):1-4. Available from: https://gorm.com.tr/index.php/GORM/article/view/120

Issue

Section

Obstetrics; Maternal Fetal Medicine and Perinatology