Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery




Antibiotic prophylaxis, Cefazolin, Surgical site infection, Topical rifamycin


OBJECTIVE: Antibiotic prophylaxis is one of the most important steps to reduce surgical site infections. First-generation cephalosporin (cefazolin) is used prophylactically in the majority of operations. Rifamycin is a broad-spectrum semisynthetic antibiotic that is bactericidal against gram (+) and gram (˗) microorganisms. To the best of our knowledge, there are no studies on the use of rifamycin in antibiotic prophylaxis. In this study, we aimed to analyze whether there is a difference between the use of only cefazolin and only rifamycin in terms of surgical site infections.

STUDY DESIGN: One hundred patients were included in this case-control study during the last quarter period of 2017. These patients (n=100) were divided into two groups according to their antibiotic use; 50 patients who received only 1 g cefazolin constituted Group 1, 50 patients who received only 250 mg topical rifamycin over the incision line based on surgeon’s preference constituted Group 2.

RESULTS: The use of prophylactic topical rifamycin reduced the incidence of wound infection. compared with cefazolin. Surgical site infection was detected in 5 (10%) of the patients who received cefazolin, whereas surgical site infection was not observed in patients who received rifamycin (p=0.022).

CONCLUSIONS: The use of topical rifamycin is effective but does not imply that systemic antibiotics should replace prophylaxis. The use of rifamycin would aid in systemic antibiotic prophylaxis.


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How to Cite

Ata N, Kulhan M, Kulhan NG, Turkler C, Bilgi A, Celik C. Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery. Gynecol Obstet Reprod Med [Internet]. 2022Mar.30 [cited 2022Aug.17];28(1):76-81. Available from:



Gynecology and Gynecological Oncology

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