Ocular Surface Disease Severity in Polycystic Ovary Syndrome: is This Really Significant in Daily Life?





Ocular surface, Meibomian gland, Polycystic ovary syndrome, Tear osmolarity


OBJECTIVE: The purpose of this study was to ascertain the extent to which the ocular surface of women with polycystic ovary syndrome is impacted.

STUDY DESIGN: Included in this case-control study were 23 eyes of 23 patients (Group I) with polycystic ovary syndrome and 10 eyes of 10 healthy subjects (Group II). Polycystic ovary syndrome was diagnosed when two of the following conditions were met: oligo- or anovulation, clinical and/or biochemical signs of hyperandrogenism, and ultrasonographic documentation of polycystic ovaries. Ocular surface disease grading was performed using the Ocular Surface Disease Index questionnaire, slit lamp examination, meibomian gland secretion scoring, tear film breakup time, staining scores of ocular surfaces, the Schirmer's test, and tear osmolarity assessment.

RESULTS: The study observed no significant difference in age (p=0.896). Group I was found to have a significantly higher median luteinizing hormone level (p=0.027). The Ocular Surface Disease Index scores in group I were significantly higher than those in group II (p=0.031). The prevalence of anterior blepharitis was significantly greater in group I (p=0.05). Tear film breakup time was higher in group I than in group II (p=0.026). The ocular surface disease severity was found to be significantly higher in group I (p=0.03). In group I, Ocular Surface Disease Index scores were significantly positively correlated with free testosterone, while tear osmolarity was significantly positively correlated with estradiol levels but significantly negatively correlated with dehydroepiandrosterone sulfate levels (p<0.05).

CONCLUSIONS: Daily activities appear to be slightly impaired in patients with polycystic ovary syndrome due to ocular surface problems. However, environmental factors (humidity, temperature, etc.) contribute to the aggravation of ocular symptoms. Patients with polycystic ovary syndrome may be referred to an ophthalmologist to preserve ocular surface health.


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Author Biographies

Demet Yabanoglu, Hacettepe University

Department of Ophthalmology

Funda Gode, Izmir Medical Park Hospital

Department of Obstetrics and Gynaecology




How to Cite

Yabanoglu D, Gode F. Ocular Surface Disease Severity in Polycystic Ovary Syndrome: is This Really Significant in Daily Life?. Gynecol Obstet Reprod Med [Internet]. 2022Mar.30 [cited 2022May20];28(1):62-8. Available from: https://gorm.com.tr/index.php/GORM/article/view/1173



Reproductive Medicine: Endocrinology and Infertility