Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis?

Hasan Eroglu; Harun Egemen Tolunay; Kemal Sarsmaz; Gokcen Orgul; Dilek Sahin; Aykan Yucel

doi:10.21613/GORM.2020.1064

Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis?

Authors

Hasan Eroglu Etlik Zübeyde Hanım Kadın Hastalıkları EAH https://orcid.org/0000-0002-1180-5299
Harun Egemen Tolunay Etlik Zübeyde Hanım Kadın Hastalıkları EAH https://orcid.org/0000-0002-8922-4400
Kemal Sarsmaz Etlik Zübeyde Hanım Kadın Hastalıkları EAH https://orcid.org/0000-0003-0028-3576
Gokcen Orgul Etlik Zübeyde Hanım Kadın Hastalıkları EAH https://orcid.org/0000-0003-0578-4230
Dilek Sahin Etlik Zübeyde Hanım Kadın Hastalıkları EAH https://orcid.org/0000-0001-8567-9048
Aykan Yucel Etlik Zübeyde Hanım Kadın Hastalıkları EAH https://orcid.org/0000-0002-5888-692X

DOI:

https://doi.org/10.21613/GORM.2020.1064

Keywords:

Intrahepatic cholestasis of pregnancy, Neutrophil to lymphocyte ratio, Mean platelet volume

Abstract

OBJECTIVES: We aimed to determine whether mean platelet volume value and/or neutrophil/lymphocyte ratio values are useful as a predictive marker for gestational cholestasis.

STUDY DESIGN: Retrospective analysis of the data of patients diagnosed with pregnancy cholestasis between 2018-2019 in a perinatology clinic. 352 pregnant women were enrolled in the study (122 pregnant women with Intrahepatic cholestasis as study group and 230 pregnant women with no morbidity as the control group)

RESULTS: Mean platelet volume was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 9.30 (7-18) and 8.6 (6.7-11.5), respectively. The neutrophil/lymphocyte ratio was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 3.93 (0.46-13.75) and 4.25 (0.87-17.1), respectively. There was a statistically significant difference between the two groups for mean platelet volume (p <0.001). In the roc analysis, 8.85 fL for mean platelet volume had a sensitivity of 65% and a specificity of 59%.

CONCLUSION: When compared with healthy pregnancies, mean platelet volume value in gestational cholestasis increases significantly. However, the predictive strength of mean platelet volume for cholestasis is not strong enough to recommend its usage as a single parameter in clinical practice.

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Published

2021-08-02

How to Cite

Eroglu H, Tolunay HE, Sarsmaz K, Orgul G, Sahin D, Yucel A. Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis?. Gynecol Obstet Reprod Med [Internet]. 2021Aug.2 [cited 2024Nov.24];27(2):105-8. Available from: https://gorm.com.tr/index.php/GORM/article/view/1064

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Issue

Vol. 27 No. 2 (2021)

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

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