Immunohistochemical Evaluation of TGF-ß Isoforms in Cases with Ovarian Endometriosis and Follicular Cyst

Abdulmuttalip Şentaş
Murat İnal
Muzaffer Sancı
Yusuf Yıldırım
Sevinç İnan
Seda Vatansever
Nilgün Dicle
Çiğdem İspahi
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OBJECTIVE: To evaluate the distribution of Transforming Growth Factor (TGF)-ß1, ß2 and ß3 in surgical specimens of the cases with endometriosis and follicular cysts.
STUDY DESIGN: This prospective clinical study was carried out at Aegean Obstetrics and Gynecology Training and Research Hospital, a tertiary referral center. A total of 44 reproductive aged women operated because of adnexial masses and revealed pathologic diagnosis’ like endometriosis (Group I; n: 22 cases) and follicular cyst (Group II; n: 22 cases) were enrolled into the study. A semi-quantitative examination of immunohistochemical staining was evaluated as light (+), medium (++) and strong (+++). According to these staining levels, each case was scored as having one, two or three points; and mean scores were calculated for the groups.
RESULTS: TGF-ß1, TGF-ß2 and TGF-ß3 staining scores were (48.5±3.1), (25.4±2.3), and (43.7±2.9) in Group I; and (29.2±2.5), (26.5±2.2), and (41.1±3.0) in Group II, respectively. In contrast to the other two isoforms, TGF-ß1’s immunoreactivity was significantly higher in cases with endometriosis (p<0.01).
CONCLUSION: Ovarian tissue TGF-ß1 immunoreactivity was significantly increased in endometriosis cases when compared with follicular cyst. There are needed further studies to elucidate the importance of this finding in the pathogenesis of endometriosis.


Transforming Growth Factor (TGF)-ß isoforms, endometriosis, follicular cyst

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