Treatment of Non - Complicated Lower Urinary Tract Infection in Pregnancy: Single Dose Fosfomycin Tromethamine Versus Multiple Dose Nitrofurantoin

Authors

  • Murat Özel Zekai Tahir Burak Woman Health Education and Research Hospital, Division of Perinatology, Ankara
  • Oktay Kaymak Zekai Tahir Burak Woman Health Education and Research Hospital, Division of Perinatology, Ankara
  • Nüvit Birgili Zekai Tahir Burak Woman Health Education and Research Hospital, Division of Perinatology, Ankara
  • Şevki Çelen Zekai Tahir Burak Woman Health Education and Research Hospital, Division of Perinatology, Ankara
  • Mine Erdoğan Zekai Tahir Burak Woman Health Education and Research Hospital, Division of Perinatology, Ankara
  • Nuri Danışman Zekai Tahir Burak Woman Health Education and Research Hospital, Division of Perinatology, Ankara

Keywords:

Urinary tract infections, Pregnancy, Fosfomycin tromethamine, Nitrofurantoin

Abstract

OBJECTIVE: To evaluate the efficacy of single-dose fosfomycin tromethamine (FT) treatment in pregnant women with uncomplicated lower urinary tract infection (UTI).
STUDY DESIGN: In this study, 421 pregnant women with established, symptomatic, uncomplicated lower UTI were randomly allocated to receive either a single dose of FT (Monurol®, Zambon Group S.p.A, Milan-ITALY) (n=217) or a 7-day course of nitrofurantoin (n=204). The treatment was found to be effective if urine culture was negative 15 days after therapy.
RESULTS: Microbiological cure was achieved in 205 (94.5%) patients treated with FT and 164 (80.4%) patients treated with nitrofurantoin (p<0.05). Pathogen microorganisms were predominantly E.coli (199 in FT and 183 in NF group) followed by Klebsiella (18 in FT and 21 in NF group).
CONCLUSION: The treatment of acut lower UTI in pregnant women is essential. FT is an effective, safe, single dose treatment choice in the management of uncomplicated lower UTI in pregnant women.

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Published

2011-04-09

How to Cite

1.
Özel M, Kaymak O, Birgili N, Çelen Şevki, Erdoğan M, Danışman N. Treatment of Non - Complicated Lower Urinary Tract Infection in Pregnancy: Single Dose Fosfomycin Tromethamine Versus Multiple Dose Nitrofurantoin. Gynecol Obstet Reprod Med [Internet]. 2011Apr.9 [cited 2024Apr.20];17(1):20-3. Available from: https://gorm.com.tr/index.php/GORM/article/view/281

Issue

Vol. 17 No. 1 (2011)

Section

Obstetrics; Maternal Fetal Medicine and Perinatology

License

CC BY

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