Comparison of the Effects of Copper T and Levonorgestrel IUD on Proteoglycan Composition of Cervical Mucus

Yeşim Bayoğlu Tekin
Emine Seda Güvendağ Güven
Zihni Açar Yazıcı
Aynur Kırbaş
Figen Kır Şahin
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Abstract

OBJECTIVE: The aim of this study was to determine the effects of Copper T and Levonorgestrel IUD (LNG-IUD) on the proteoglycan composition of cervical mucus.
STUDY DESIGN: This was a cross-sectional study that was conducted at a gynecology outpatient clinic of a University hospital for a six month period. The study participants were between 18-50 years old, using either Copper T or LNG-IUD for contraception. Cervical mucus samples were collected 7 days after the menstrual bleeding and the levels of hyaluronan (HA), heparin sulfate (HS) and sulfated-glycosaminoglycans (s-GAG) were evaluated.
RESULTS: The levels of HA, HS and s-GAG in the Copper-T and LNG-IUD groups were higher than those of the controls. However, the difference was statistically significant only for s-GAG (p<0.001).
CONCLUSION: Copper T and Levonorgestrel intrauterine contraceptive devices have significant effects on proteoglycan component of cervical mucus.

Keywords

Cervical mucus, Copper T IUD, Levonorgestrel IUD


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