The Alterations in Peripheral Blood Components of Women with Abnormal Cervical Cytology

Authors

  • Mine Kiseli Ufuk University Faculty of Medicine Department of Obstetrics and Gynecology, Ankara
  • Aslı Yarcı Gürsoy Ufuk University Faculty of Medicine Department of Obstetrics and Gynecology, Ankara
  • Egemen Akıncıoğlu Ufuk University Faculty of Medicine Department of Pathology, Ankara
  • Emre Göksan Pabuçcu Ufuk University Faculty of Medicine Department of Obstetrics and Gynecology, Ankara
  • Gamze Sinem Çağlar Ufuk University Faculty of Medicine Department of Obstetrics and Gynecology, Ankara
  • Hande Esra Koca Ufuk University Faculty of Medicine Department of Obstetrics and Gynecology, Ankara
  • Zehra Edebal Ufuk University Faculty of Medicine Department of Pathology, Ankara
  • Haldun Umudum Ufuk University Faculty of Medicine Department of Pathology, Ankara

DOI:

https://doi.org/10.21613/GORM.2016.109

Keywords:

Cervicovaginal smear, Atypical squamous cells of undetermined significance, Neutrophil/lymphocyte ratio, Platelet/lymphocyte ratio

Abstract

OBJECTIVE: To investigate the peripheral blood components, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratios (PLR) in cervical cytological abnormalities.
STUDY DESIGN: We retrospectively analyzed 185 cases with abnormal and 303 cases with normal cervicovaginal smears (CVS) with blood count profile, from a total number of 9286 patients.
RESULTS: Abnormal CVS results consisted of 137 (72%) ASC-US, 16 (8%) ASC-H, 19 (10%) L-SIL, 4 (2%) H-SIL and 9 (4%) AGUS. NLR and PLR of abnormal CVS group were higher than control group (p<0.001). The lymphocyte count was significantly lower in abnormal CVS cases (p<0.001). The number of patients with neutrophilia (neutrophils ≥70% of the total leukocytes) was similar among two groups
(p>0.05).
CONCLUSION: Neutrophilia is not observed in cervical preinvasive lesions whereas it is common in cervical cancer. In this study, absence of increased neutrophil counts and presence of lymphopenia in patients with abnormal cervical cytology, may indicate an early measure in cervical pathologies.

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Published

2016-04-29

How to Cite

1.
Kiseli M, Gürsoy AY, Akıncıoğlu E, Pabuçcu EG, Çağlar GS, Koca HE, Edebal Z, Umudum H. The Alterations in Peripheral Blood Components of Women with Abnormal Cervical Cytology. Gynecol Obstet Reprod Med [Internet]. 2016Apr.29 [cited 2024Dec.29];22(1):36-9. Available from: https://gorm.com.tr/index.php/GORM/article/view/109

Issue

Vol. 22 No. 1 (2016)

Section

Gynecology and Gynecological Oncology

License

CC BY

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