TY - JOUR AU - Alanay, Yasemin AU - Gümüş, Ersin AU - Sekkin, Miray AU - Güler, Sebile AU - Çakar, Nur PY - 2006/04/17 Y2 - 2024/03/28 TI - Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality JF - Gynecology Obstetrics & Reproductive Medicine JA - Gynecol Obstet Reprod Med VL - 12 IS - 1 SE - Review DO - UR - https://gorm.com.tr/index.php/GORM/article/view/572 SP - 70-78 AB - <p>Asymmetry of the left-right (L-R) axis is a feature of vertebrates that is apparent in the viscera and vasculature. An understanding of L-R patterning in human dev elopment is aided by familiarity with key events and important pathways in mammalian embryogenesis.The induction of L-R asymmetry follows the establishment of the anteroposterior (A-P or rostrocaudal) and dorsov entral (D-V) axes and requires the pre-existing midline symmetry to be broken before sidedness is induced via a series of complex, coordinated molecular signaling events. In this review, our aim is to describe the molecular background of this embryological process, and give brief knowledge concerning its clinical consequences.</p> ER -