@article{Tuten_Acikgoz_Mammadov_Malik_Tuten_Guralp_2021, place={Ankara, TR}, title={Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis?}, volume={27}, url={https://gorm.com.tr/index.php/GORM/article/view/949}, DOI={10.21613/GORM.2019.949}, abstractNote={<p><strong>Objective:</strong> To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis.</p><p><strong>Study design:</strong> A total of 53 women with endometriosis and 37 women without endometriosis were evaluated in a, case-controlled study. The demographic features, clinical, and laboratory parameters of the two groups were compared.</p><p><strong>Results:</strong> The serum 25-hydroxy vitamin D levels were significantly decreased in both stage 1-2 and stage 3-4 groups compared to the controls (p<0.001 and p<0.001); although the difference between the stage 1-2 and stage 3-4 groups remained nonsignificant. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma (8.4±2.7 ng/mL vs 11.1±5.6 ng/mL, p=0.047). Mean serum 25-hydroxy vitamin D levels in women with and without dysmenorrhea were not significantly different from each other in the endometriosis and non-endometriosis subgroups. Serum 25-hydroxy vitamin D had no correlation with dysmenorrhea-VAS scores (r=-0.157, p=0.267).</p><p><strong>Conclusion:</strong> The mean serum 25-hydroxy vitamin D levels were significantly decreased in both mild and moderate to severe endometriosis groups compared to the controls. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma.</p>}, number={2}, journal={Gynecology Obstetrics & Reproductive Medicine}, author={Tuten, Nevin and Acikgoz, Serdar and Mammadov, Zahid and Malik, Eduard and Tuten, Abdullah and Guralp, Onur}, year={2021}, month={Aug.}, pages={132–137} }