@article{Sutcu_Varol_Inan_Uzun_Sayin_2022, place={Ankara, TR}, title={Early Serum Heme Oxygenase-1, Soluble Vascular Endothelial Growth Factor Receptor-1, and B-Cell Lymphoma/Leukemia-2 Levels and Unfavorable Obstetric Outcomes}, volume={28}, url={https://gorm.com.tr/index.php/GORM/article/view/1177}, DOI={10.21613/GORM.2021.1177}, abstractNote={<p><strong>OBJECTIVE:</strong> To examine early pregnancy levels of serum heme oxygenase-1, soluble vascular endothelial growth factor receptor-1, B-cell lymphoma/leukemia-2 in relation to unfavorable pregnancy outcomes, including preeclampsia, fetal growth restriction, spontaneous preterm birth, gestational diabetes mellitus and fetal macrosomia.</p> <p><strong>STUDY DESIGN:</strong> A total of randomly selected 140 pregnancies were included in this prospective study. Peripheral blood samples were obtained between 110/7 and 136/7 gestational weeks. All pregnancies were followed up until the outcomes were obtained and classified as preeclampsia, fetal growth restriction, spontaneous preterm birth, gestational diabetes mellitus, fetal macrosomia, and uncomplicated ones. </p> <p><strong>RESULTS:</strong> Significantly high levels of early serum heme oxygenase-1 were found in the cases who subsequently developed preeclampsia, spontaneous preterm birth, and fetal macrosomia (p<0.05), in concordance with high soluble vascular endothelial growth factor receptor-1 levels of the preeclampsia group, however, B-cell lymphoma/leukemia-2 s were similar in all groups. As soluble vascular endothelial growth factor receptor-1 predicted preeclampsia at a value of 11.905 ng/mL, the cutoff values for the heme oxygenase-1 to predict preeclampsia, spontaneous preterm birth, and fetal macrosomia were 0.372 ng/mL, 0.354 ng/mL and 0.494 ng/ml, respectively. </p> <p><strong>CONCLUSION:</strong> Elevated first trimester heme oxygenase-1 levels are remarkable in the pregnancies associated with preeclampsia, spontaneous preterm birth, and fetal macrosomia in comparison with uncomplicated ones. </p>}, number={2}, journal={Gynecology Obstetrics & Reproductive Medicine}, author={Sutcu, Havva and Varol, G. Fusun and Inan, Cihan and Uzun, Isil and Sayin, N.Cenk}, year={2022}, month={Aug.}, pages={122–128} }