@article{Abdelazim_AbuFaza_Al-Ajmi_Amer_Shikanova_Karimova_2022, place={Ankara, TR}, title={Heme-Iron OptiFer® in the Treatment of Iron Deficiency Anemia During Pregnancy }, volume={28}, url={https://gorm.com.tr/index.php/GORM/article/view/1147}, DOI={10.21613/GORM.2020.1147}, abstractNote={<p><strong>OBJECTIVES:</strong> This study designed to compare the efficacy, and tolerability of heme-iron OptiFer® to ferrous fumarate in the treatment of iron deficiency anemia during pregnancy.</p> <p><strong>STUDY DESIGN:</strong> Two hundred and thirty-four (234) women with iron deficiency anemia during pregnancy were included in this study; 121 women in the heme-iron OptiFer® group, and 113 women in the ferrous fumarate group. Women in the heme-iron OptiFer® group received OptiFer® tablets twice daily for ≥3 months then once daily as a maintenance dose. Women in the ferrous fumarate group received 350 mg oral ferrous fumarate once daily for ≥3 months. The pre-treatment ferritin, hemoglobin, red blood cells-mean corpuscular volume, and red blood cells-mean corpuscular hemoglobin were compared by the post-treatment values in the two studies.</p> <p><strong>RESULTS:</strong> The post-treatment hemoglobin and ferritin were significantly high in the heme-iron OptiFer® group (11.2±7.1 gm/dL and 112.8±54.8 ug/l, respectively) compared to the ferrous fumarate group (10.9 ±5.1 and 89.9±43.3, respectively; p=0.0002 and p=0.006; respectively). The post-treatment red blood cells-mean corpuscular volume and red blood cells-mean corpuscular hemoglobin were significantly high in the heme-iron OptiFer® group (92.0±4.1 fl and 31.9±6.2 pg, respectively) compared to the ferrous fumarate group (87.7±2.9 and 28.5±4.7, respectively; p=0.0001 and p=0.001, respectively). The rates of poor compliance and gastrointestinal intolerance were significantly high in the ferrous fumarate group compared to the heme-iron OptiFer® group (12.4% and 19.5%, respectively versus 3.3% and 2.5%, respectively), (p=0.01 and p=0.0001, respectively). </p> <p><strong>CONCLUSION:</strong> Heme-iron OptiFer® is an effective therapeutic option for the treatment of iron deficiency anemia during pregnancy with low side effects. heme-iron OptiFer® can be used in women who have low compliance, and/or gastrointestinal intolerance to conventional iron salts.</p>}, number={1}, journal={Gynecology Obstetrics & Reproductive Medicine}, author={Abdelazim, Ibrahim A. and AbuFaza, Mohannad and Al-Ajmi, Soud M. and Amer, Osama O. and Shikanova, Svetlana and Karimova, Bakyt}, year={2022}, month={Mar.}, pages={1–6} }