Comparison of Survival Outcomes of Lymphovascular Space Invasion-Negative and Lymphovascular Space Invasion - Positive Women with Stage IIIC Endometrioid Endometrial Cancer: A Case - Control Study

Authors

  • Zeliha Firat Cuylan Department of Gynecologic Oncology, Zekai Tahir Burak Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey. http://orcid.org/0000-0003-3382-8763
  • Mehmet Mutlu Meydanli Department of Gynecologic Oncology, Zekai Tahir Burak Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey. https://orcid.org/0000-0001-6763-9720
  • Murat Öz Department of Gynecologic Oncology, Zekai Tahir Burak Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey. https://orcid.org/0000-0002-0629-5386
  • Ahmet Taner Turan Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey. https://orcid.org/0000-0001-8120-1143
  • Ozgur Akbayir Department of Gynecologic Oncology, Kanuni Sultan Suleyman Teaching and Research Hospital, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey https://orcid.org/0000-0002-2699-4969
  • Murat Dede Department of Obstetrics and Gynecology, Anadolu Medical Center, Kocaeli, Turkey. https://orcid.org/0000-0002-6361-3256
  • Ali Ayhan Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Baskent University, Ankara, Turkey. https://orcid.org/0000-0001-7155-9096

DOI:

https://doi.org/10.21613/GORM.2019.925

Keywords:

Endometrioid - type endometrial cancer, Lymphovascular space invasion, Stage IIIC disease, Overall survival

Abstract

Objective: The purpose of this case-control study was to investigate the effect of lymphovascular space invasion on recurrence patterns and survival in patients with stage IIIC endometrioid type endometrial cancer.

Study Design: A multicenter, retrospective, department database review was performed to identify lymphovascular space invasion-negative and lymphovascular space invasion-positive stage IIIC endometrioid endometrial cancer at five gynecological oncology centers in Turkey. Demographic, clinicopathological and survival data were collected. Cases and controls were matched in terms of age at diagnosis, grade of tumor, depth of myometrial invasion, sub-stage and adjuvant treatment.

Results: Forty-one patients in the case group and 82 patients in the control group were eligible for the study. The 5-year OS rates were 94.4% in the lymphovascular space invasion-negative group and 77.2% in the LVSI-positive group (p=0.058). Advanced age (58 years) (HR 3.73; 95% CI: 1.19-11.69, p=0.02), grade 3 tumor (HR 2.57; 95% CI: 1.002-6.62, p=0.048) and cervical involvement (HR 2.62; 95% CI: 1.03-6.67, p= 0.04) appeared to be as independent predictors of decreased overall survival (OS). There was a trend towards statistical significance between the presence of lymphovascular space invasion and OS in regression analysis (HR 3.10; 95% CI 0.90-10.67, p=0.05). Recurrence rates were 17.0% (7/41) and 24.4% (20/82) in lymphovascular space invasion-negative and lymphovascular space invasion-positive groups, respectively (p=0.48). There were 5 cases of retroperitoneal recurrences in the lymphovascular space invasion-positive group and no retroperitoneal recurrence among lymphovascular space invasion-negative women.

Conclusion: Lymphovascular space invasion status seems to be of borderline significance for OS in stage IIIC endometrioid endometrial cancer and impacts recurrence patterns as retroperitoneal recurrences are strongly related to positive lymphovascular space invasion status.

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Published

2021-04-16

How to Cite

1.
Cuylan ZF, Meydanli MM, Öz M, Turan AT, Akbayir O, Dede M, Ayhan A. Comparison of Survival Outcomes of Lymphovascular Space Invasion-Negative and Lymphovascular Space Invasion - Positive Women with Stage IIIC Endometrioid Endometrial Cancer: A Case - Control Study. Gynecol Obstet Reprod Med [Internet]. 2021Apr.16 [cited 2024Apr.18];27(1):72-8. Available from: https://gorm.com.tr/index.php/GORM/article/view/925

Issue

Vol. 27 No. 1 (2021)

Section

Gynecology and Gynecological Oncology

License

Copyright (c) 2020 Zeliha Firat Cuylan, Mehmet Mutlu Meydanli, Murat Öz, Ahmet Taner Turan, Ozgur Akbayir, Murat Dede, Ali Ayhan

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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