Risk of Malignancy Index Has a Poor Sensitivity in Detecting Borderline Epithelial Tumors and Non-Epithelial Ovarian Tumors

Authors

DOI:

https://doi.org/10.21613/GORM.2018.847

Keywords:

Risk of malignancy index, Sensivity, Adnexal, Mass, Ovarian, Cancer, Epithelial, Non-epithelial, Borderline

Abstract

Objectives: To evaluate diagnostic accuracy of "Risk Of Malignancy İndex-1" (RMI-1) for postmenopausal adnexal masses.

Study Design: Fifty postmenopausal women who had undergone surgery because of adnexal masses were included in this prospective study. RMI-1 scores were calculated through the formula: [RMI= Ultrasound Score x Menopause Score x Serum Ca-125 Level] and noted preoperatively by the same sonographer for each case. "Final histopathological diagnosis" was accepted as gold standard for benign-malignant categorical distribution. Borderline tumors were categorized in malignant tumor group.

Results: According to final histopathological results; 20 of the 50 patients had malignant adnexal masses. Twelve of them had invasive epithelial tumors. The remaining 8 patients had borderline epithelial tumors or non-epithelial ovarian cancers. When the RMI score ≥200 was accepted as a positive test result compatible with the literature; we calculated the sensitivity: 75%, specificity: 93%, positive predictive value: 88%, negative predictive value: 85% predicting malignant adnexal masses. All of the 12 patients with invasive epithelial tumors had RMI-1 scores higher than 200. Nevertheless, only 3 of the 8 patients with borderline epithelial tumors or non-epithelial ovarian cancers had RMI-1 scores higher than 200. We have found out that invasive epithelial tumors had higher USG Scores, Ca-125 Levels and RMI Scores when compared to borderline epithelial tumors and non-epithelial ovarian cancers and the difference was statistically significant.

Conclusions: RMI-1 is a valuable and applicable method in the initial evaluation of postmenopausal patients with adnexal masses. İt has a high diagnostic performance in detecting invasive epithelial ovarian cancers, but it has a poor sensitivity in detecting borderline ovarian tumors and non-epithelial ovarian cancers.

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Author Biographies

Yasin Durmus, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey

Gynecological Oncology, M.D.

Mehmet Mutlu Meydanli, Zekai Tahir Burak Women's Health Teaching and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey

Gynecological Oncology, Prof.

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Published

2019-08-30

How to Cite

1.
Durmus Y, Meydanli MM. Risk of Malignancy Index Has a Poor Sensitivity in Detecting Borderline Epithelial Tumors and Non-Epithelial Ovarian Tumors. Gynecol Obstet Reprod Med [Internet]. 2019Aug.30 [cited 2024Mar.29];25(2):101-6. Available from: https://gorm.com.tr/index.php/GORM/article/view/847

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Section

Gynecology and Gynecological Oncology