The Role of Human Papilloma Virus in Synchronous Gynecologic Malignancies: A Report of Two Cases and Review of the Literature

Authors

  • Salih Taşkın Ankara University School of Medicine Department of Obstetrics and Gynecology, Ankara
  • Emre Göksan Pabuçcu Karaman State Hospital Department of Obstetrics and Gynecology, Karaman
  • Alper Kahraman Ankara University School of Medicine Department of Obstetrics and Gynecology, Ankara
  • İbrahim Yalçın Ankara University School of Medicine Department of Obstetrics and Gynecology, Ankara
  • Uğur Fırat Ortaç Ankara University School of Medicine Department of Obstetrics and Gynecology, Ankara

Keywords:

Cervical carcinoma, Endometrial carcinoma, Human papilloma virus, Synchronous cancer

Abstract

Aim of the paper is to investigate the suspicious role of HPV in synchronous endometrial and cervical carcinomas and to discuss the relation between HPV and endometrium epithelium. The first case is 68- year-old and the second case is 56 year-old postmenopausal woman who were diagnosed with invasive cervical carcinoma synchronously with endometrial carcinoma. Following surgical procedures, high risk HPV DNA analysis using PCR were undertaken in both cases to investigate the possible role of HPV in synchronous malignancies. All endometrial samples were considered as negative for high risk HPV types however all cervical samples were considered as positive. Unlike cervical pathologies, HPV does not seem to play active role as etiologic agent in endometrial neoplasms, even detected synchronously with invasive cervical cancers.

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Published

2015-04-30

How to Cite

1.
Taşkın S, Pabuçcu EG, Kahraman A, Yalçın İbrahim, Ortaç UF. The Role of Human Papilloma Virus in Synchronous Gynecologic Malignancies: A Report of Two Cases and Review of the Literature. Gynecol Obstet Reprod Med [Internet]. 2015Apr.30 [cited 2024Apr.19];21(1):46-8. Available from: https://gorm.com.tr/index.php/GORM/article/view/46

Issue

Vol. 21 No. 1 (2015)

Section

Case Reports

License

Copyright (c) 2015 Salih Taşkın, Emre Göksan Pabuçcu, Alper Kahraman, İbrahim Yalçın, Uğur Fırat Ortaç

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

CC BY

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